Radiation-Induced Ischemic Heart Failure with Dual CTOs in a Young Lymphoma Survivor

Case presentation

    35 years old, male

    • Weight: 100 kg
    • Height: 185 cm
    • BMI: 29

    Cardiovascular Risk Factors: 

    • hyperomocysteinemia
    • reduced glucose tolerance

    Medical History: 

    • history of Hodgkin Lymphoma treated with chemotherapy and radiotherapy
    • thoracic outlet syndrome
    • pectus excavatum
    • ulcerative colitis
    • allergic asthma

    Lab Test

    • Hb: 14.6 g/dl
    • Creatinine: 1.08 mg/dl
    • eGFR: 118 ml/min
    • LDL 145 mg/dl
    • Lp(a) 8 mg/dl
    • PLT 386. 000/ul
    • hsTnI 863,6 pg/ml

    Admission Medical Therapy

    • Mesalazine 1200 mg twice daily

    ECG

    • STEMI - Inferior

    Transthoracic Echocardiogram

    Moderately dilated left ventricle with infero-posterior and basal infero-septal akinesia.

    LVEF estimated at 35-40%

    Moderate to severe functional mitral regurgitation.

    Coronary Angiography

    Acute thrombotic total occlusion of the mid right coronary artery.

    Chronic total occlusion of mid left anterior descending and proximal left circumflex.

     

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    Primary PCI of Right Coronary Artery

    Primary PCI and direct implantation of two overlapping DES (Onyx Frontier 2.5 x 30 mm and Onyx Frontier 3.0 x 12 mm).

    Baseline

    Post-stenting

    Clinical Course and Heart Team Discussion

    Coronary Care Unit stay

    • Improvement of symptoms after optimized medical therapy (IV nitrates and beta-blockers). 
    • Development of fever; blood cultures positive for Staphylococcus epidermidis, targeted IV antibiotic therapy initiated.
     

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Declaration of interest

    None

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